This book is from the third Avengers series. This book would be very late in my childhood collection, since it’s cover-dated for March 2001 and I would have been a senior in high school. I probably picked it up because Kurt Busiek was the writer and I always enjoyed his books.
This book takes place in the early days of Spider-Man’s career, but unlike Ultimate Spider-Man, this took place in the 616-universe, the main Marvel Universe. There are references to the original Stan Lee/Steve Ditko books but I don’t remember feeling like I had to find 35-year-old comics to follow them.